Mutational Tuning of Galectin-3 Specificity and Biological Function

Mutational Tuning of Galectin-3 Specificity and Biological Function*

Galectins are defined by a conserved β-galactoside binding site that has been linked to many of their important functions in e.g. cell adhesion, signaling, and intracellular trafficking. Weak adjacent sites may enhance or decrease affinity for natural β-galactoside-containing glycoconjugates, but little is known about the biological role of this modulation of affinity (fine specificity). We hav...

Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction Weir et al: Galectin-3 Post-Infarction Remodeling

Immunolocalization of Galectin-3 in Mouse Testicular Tissue

Objective(s) Galectin-3 (Gal-3) is a member of the B-galactoside-binding lectins which is expressed in a variety of tissues and plays a role in diverse biological events, such as embryogenesis, adhesion, cellular proliferation, and apoptosis. In this study, the presence and distribution of galectin-3 (Gal-3) in the mouse testicular tissue was investigated. Materials and Methods Eight adult N...

Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: implication of galectin-3 function during metastasis.

Galectin-3 is a beta-galactoside-binding protein which regulates many biological processes including cell adhesion, migration, cell growth, tumor progression, metastasis, and apoptosis. Although the exact function of galectin-3 in cancer development is unclear, galectin-3 expression is associated with neoplastic progression and metastatic potential. Since studies have suggested that tumor cell ...

Evaluation of galectin-3 expression in ameloblastoma stromal fibroblasts and its association with recurrence

Introduction: Ameloblastoma is a benign odontogenic neoplasm with a high risk of recurrence. Ameloblastoma stromal fibroblasts are associated with tumor growth and invasion; however, a few studies have evaluated the immunohistochemical characteristics of stromal fibroblasts and their association with recurrence in Ameloblastoma. Galectin-3 (gal-3) is a member of the B-galactoside bonding protei...